Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome
نویسندگان
چکیده
منابع مشابه
PReS13-SPK-1292: Gut microbiome and metabolism
The enormous number and diversity of microorganisms in the human gastrointestinal tract support the host in many functions such as digestion of complex carbohydrates. The relationship between the gut microbiota and energy homeostasis, metabolic dysfunction and inflammation and their role in the pathogenesis of obesity-related disorders is increasingly recognized. Obesity developing in genetical...
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The giant panda genome codes for all necessary enzymes associated with a carnivorous digestive system but lacks genes for enzymes needed to digest cellulose, the principal component of their bamboo diet. It has been posited that this iconic species must therefore possess microbial symbionts capable of metabolizing cellulose, but these symbionts have remained undetected. Here we examined 5,522 p...
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Personalized Nutrition and the Microbiome The intersection of personalized nutrition and the human microbiome represents an exciting new science. Within this emerging and complex arena, the human microbiome and the impact of dietary components has been the target of approximately 4,000 publications over the past four decades. The field of paleomicrobiology recently reported—based on findings fr...
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PURPOSE OF REVIEW The mammalian mucosal surfaces are densely inhabited by a diverse microbial ecosystem termed the microbiota. Among these highly heterogeneous populations, the largest and richest is the gut microbiota, recently suggested to affect various physiological traits and susceptibility to disease. Novel metagenomic and metabolomic approaches, which have been developed in the past deca...
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The composition of the gut microbiome is hypothesized to be an environmental factor that contributes to obesity. Results of several human studies suggest that obesity is associated with differences in the gut microbiota composition, reduced bacterial diversity, and altered representation of bacterial metabolic pathways. The obese phenotype is associated with increased microbial fermentation and...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2020
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20198982